QdoR

• Description: transcriptional regulator (TetR family), control of qdoI-yxaH and lmrA-lmrB
  
  

Gene name	qdoR
Synonyms	yxaF
Essential	no
Product	transcriptional regulator
Function	control of quercetin utilization
Gene expression levels in SubtiExpress: qdoR
MW, pI	20 kDa, 6.111
Gene length, protein length	573 bp, 191 aa
Immediate neighbours	qdoI, yxnA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

LmrA regulon, QdoR regulon

The QdoR regulon:

• qdoI-yxaH, qdoR

The gene

Basic information

• Locus tag: BSU39990

Database entries

• BsubCyc: BSU39990

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: TetR family

• Paralogous protein(s): LmrA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: flavonoids such as quercetin act as molecular inducers and result in release from DNA targets PubMed

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU39990

• Structure: 1SGM

• UniProt: P42105

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: qdoR PubMed

• Expression browser: qdoR PubMed

• Sigma factor:

• Regulation:
  • induced by flavonoids such as quercetin (QdoR, LmrA) PubMed

• Regulatory mechanism:
  • LmrA: transcription repression PubMed
  • QdoR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Yasutaro Fujita, University of Fukuyama, Japan

References

Reviews

Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471] [WorldCat.org] [DOI] (I p)