TagH

• Description: ABC transporter for teichoic acid translocation (ATP-binding protein)
  
  

Gene name	tagH
Synonyms
Essential	yes PubMed
Product	ABC transporter for teichoic acid translocation (ATP-binding protein)
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: tagH
Interactions involving this protein in SubtInteract: TagH
MW, pI	59 kDa, 9.447
Gene length, protein length	1581 bp, 527 aa
Immediate neighbours	yvzE, tagG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, ABC transporters, biosynthesis of cell wall components, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU35700

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU35700

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + H₂O + teichoic acid(In) = ADP + phosphate + teichoic acid(Out) (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TagG-TagH PubMed

• Localization: membrane associated (via TagG) PubMed

Database entries

• BsubCyc: BSU35700

• Structure:

• UniProt: P42954

• KEGG entry: [2]

• E.C. number: 3.6.3.40

Expression and regulation

• Operon:

• Expression browser: tagH PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Kathrin Schirner, Laura K Stone, Suzanne Walker
ABC transporters required for export of wall teichoic acids do not discriminate between different main chain polymers.
ACS Chem Biol: 2011, 6(5);407-12
[PubMed:21280653] [WorldCat.org] [DOI] (I p)

Alex Formstone, Rut Carballido-López, Philippe Noirot, Jeffery Errington, Dirk-Jan Scheffers
Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis.
J Bacteriol: 2008, 190(5);1812-21
[PubMed:18156271] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

V Lazarevic, D Karamata
The tagGH operon of Bacillus subtilis 168 encodes a two-component ABC transporter involved in the metabolism of two wall teichoic acids.
Mol Microbiol: 1995, 16(2);345-55
[PubMed:7565096] [WorldCat.org] [DOI] (P p)