SecG

• Description: preprotein translocase subunit
  
  

Gene name	secG
Synonyms	yvaL
Essential	no
Product	preprotein translocase subunit
Function	protein secretion
Gene expression levels in SubtiExpress: secG
Interactions involving this protein in SubtInteract: SecG
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	7 kDa, 10.413
Gene length, protein length	228 bp, 76 aa
Immediate neighbours	yvaK, yvaM
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

The gene

Basic information

• Locus tag: BSU33630

Database entries

• BsubCyc: BSU33630

• DBTBS entry: no entry

• SubtiList entry: [1]

Additional information

Deletion of secG from the chromosome causes a temperature sensitive secretion defect. PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secG family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (SecY-SecE-SecG)2-SecA2 PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33630

• Structure: 3DL8 (structure of the (SecY-SecE-SecG)-SecA complex) PubMed

• UniProt: O32233

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: secG-yvaK-rnr-smpB-ssrA PubMed

• Expression browser: secG PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

Ji-Hyun Shin, Chester W Price
The SsrA-SmpB ribosome rescue system is important for growth of Bacillus subtilis at low and high temperatures.
J Bacteriol: 2007, 189(10);3729-37
[PubMed:17369301] [WorldCat.org] [DOI] (P p)

K H van Wely, J Swaving, C P Broekhuizen, M Rose, W J Quax, A J Driessen
Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue.
J Bacteriol: 1999, 181(6);1786-92
[PubMed:10074070] [WorldCat.org] [DOI] (P p)