MrgA

• Description: iron storage protein, DNA-binding stress protein, forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
  
  

Gene name	mrgA
Synonyms
Essential	no
Product	mini-ferritin, DNA-binding stress protein
Function	iron storage, protection against oxidative stress
Gene expression levels in SubtiExpress: mrgA protection against oxidative stress
Metabolic function and regulation of this protein in SubtiPathways: mrgA
MW, pI	17 kDa, 4.597
Gene length, protein length	459 bp, 153 aa
Immediate neighbours	yusZ, htrB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, iron metabolism, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

• Locus tag: BSU32990

Database entries

• BsubCyc: BSU32990

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing

• Protein family: dps family (according to Swiss-Prot)

• Paralogous protein(s): Dps

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): contains an iron-sulfur cluster

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU32990

• Structure: 2CHP

• UniProt: P37960

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mrgA PubMed

• Expression browser: mrgA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by hydrogen peroxide (PerR) PubMed

• Regulatory mechanism:
  • PerR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Emilia Chiancone, Pierpaolo Ceci, Andrea Ilari, Frederica Ribacchi, Simonetta Stefanini
Iron and proteins for iron storage and detoxification.
Biometals: 2004, 17(3);197-202
[PubMed:15222465] [WorldCat.org] [DOI] (P p)