PapA

• Description: Xaa-Pro amino-peptidase
  
  

Gene name	papA
Synonyms	yqhT
Essential	no
Product	Xaa-Pro amino-peptidase
Function	degradation of proline-containing peptides
Gene expression levels in SubtiExpress: papA
Metabolic function and regulation of this protein in SubtiPathways: papA
MW, pI	37 kDa, 4.83
Gene length, protein length	1059 bp, 353 aa
Immediate neighbours	efp, yqhS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, coping with hyper-osmotic stress

The gene

Basic information

• Locus tag: BSU24460

Database entries

• BsubCyc: BSU24460

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase M24B family (according to Swiss-Prot)

• Paralogous protein(s): PapB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU24460

• Structure: 3Q6D (the B. anthracis enzyme, 65% identity, 82% similarity)

• UniProt: P54518

• KEGG entry: [2]

• E.C. number: 3.4.11.9

Expression and regulation

• Operon:

• Expression browser: papA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: available in the Erhard Bremer lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Erhard Bremer, Marburg University, Germany Homepage

References

Adrienne Zaprasis, Jeanette Brill, Marietta Thüring, Guido Wünsche, Magnus Heun, Helena Barzantny, Tamara Hoffmann, Erhard Bremer
Osmoprotection of Bacillus subtilis through import and proteolysis of proline-containing peptides.
Appl Environ Microbiol: 2013, 79(2);576-87
[PubMed:23144141] [WorldCat.org] [DOI] (I p)