RibA

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  • Description: GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene name ribA
Synonyms
Essential no
Product GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
Function riboflavin biosynthesis
Gene expression levels in SubtiExpress: ribA
Metabolic function and regulation of this protein in SubtiPathways:
ribA
MW, pI 43 kDa, 5.582
Gene length, protein length 1194 bp, 398 aa
Immediate neighbours ribH, ribE
Sequences Protein DNA DNA_with_flanks
Genetic context
RibA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RibA expression.png















Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

FMN-box

The gene

Basic information

  • Locus tag: BSU23260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 2BZ0 (from E. coli, 54% identity, 69% similarity to the C-terminal domain) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism: FMN-box: riboswitch, mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References