CotE

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  • Description: outer spore coat morphogenetic protein, controls the assembly of the outer spore coat layer

Gene name cotE
Synonyms
Essential no
Product spore coat morphogenetic protein
Function assembly of the outer spore coat
Gene expression levels in SubtiExpress: cotE
Interactions involving this protein in SubtInteract: CotE
MW, pI 20 kDa, 4.139
Gene length, protein length 543 bp, 181 aa
Immediate neighbours ymcA, mutS
Sequences Protein DNA DNA_with_flanks
Genetic context
CotE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CotE expression.png















Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigE regulon, SigK regulon, GerE regulon

CotE-dependent proteins of the outer spore coat

The gene

Basic information

  • Locus tag: BSU17030

Phenotypes of a mutant

  • mis-assembly of the outer spore coat PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: cotE family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:
  • Localization:
    • encircles the forespore with a biased accumulation on the mother cell-proximal face of the forespore PubMed
    • outer spore coat, localization depends on SpoIVA PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Arthur Aronson, Purdue University, West Lafayette, USA homepage

Adriano Henriques, Lisbon, Portugal homepage

Your additional remarks

References

Reviews

Peter T McKenney, Adam Driks, Patrick Eichenberger
The Bacillus subtilis endospore: assembly and functions of the multilayered coat.
Nat Rev Microbiol: 2013, 11(1);33-44
[PubMed:23202530] [WorldCat.org] [DOI] (I p)

Peter Setlow
Dynamics of the assembly of a complex macromolecular structure--the coat of spores of the bacterium Bacillus subtilis.
Mol Microbiol: 2012, 83(2);241-4
[PubMed:22192522] [WorldCat.org] [DOI] (I p)

Original publications