IspC

• Description: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, second step in the MEP pathway of isoprenoid biosynthesis
  
  

Gene name	ispC
Synonyms	yluB, dxr
Essential	yes PubMed
Product	1-deoxy-D-xylulose-5-phosphate reductoisomerase
Function	MEP pathway of isoprenoid biosynthesis
Gene expression levels in SubtiExpress: ispC
MW, pI	43 kDa, 5.801
Gene length, protein length	1164 bp, 388 aa
Immediate neighbours	cdsA, rasP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, essential genes

The gene

Basic information

• Locus tag: BSU16550

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU16550

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2-C-methyl-D-erythritol 4-phosphate + NADP⁺ = 1-deoxy-D-xylulose 5-phosphate + NADPH (according to Swiss-Prot)

• Protein family: DXR family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU16550

• Structure: 1R0K (from Zymomonas mobilis, 45% identity) PubMed

• UniProt: O31753

• KEGG entry: [2]

• E.C. number: 1.1.1.267

Expression and regulation

• Operon:

• Expression browser: ispC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: