FtsW

• Description: cell-division protein
  
  

Gene name	ftsW
Synonyms	ylaO
Essential	yes PubMed
Product	cell-division protein
Function	cell division
Gene expression levels in SubtiExpress: ftsW
Interactions involving this protein in SubtInteract: FtsW
MW, pI	43 kDa, 9.722
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	ylaN, pycA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, essential genes, membrane proteins

This gene is a member of the following regulons

YofA regulon

The gene

Basic information

• Locus tag: BSU14850

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU14850

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsW/rodA/spoVE family (according to Swiss-Prot) SEDS proteins (shape, elongation, division, and sporulation)

• Paralogous protein(s): RodA, SpoVE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Maf-FtsW PubMed

• Localization: membrane

Database entries

• BsubCyc: BSU14850

• Structure:

• UniProt: O07639

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsW-pycA (according to DBTBS)

• Expression browser: ftsW PubMed

• Sigma factor:

• Regulation:
  • constitutively expressed PubMed

• Regulatory mechanism:
  • YofA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Erik Nico Trip, Jan-Willem Veening, Eric J Stewart, Jeff Errington, Dirk-Jan Scheffers
Balanced transcription of cell division genes in Bacillus subtilis as revealed by single cell analysis.
Environ Microbiol: 2013, 15(12);3196-209
[PubMed:23701187] [WorldCat.org] [DOI] (I p)

Kenneth Briley, Peter Prepiak, Miguel J Dias, Jeanette Hahn, David Dubnau
Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis.
Mol Microbiol: 2011, 81(1);23-39
[PubMed:21564336] [WorldCat.org] [DOI] (I p)

Pamela Gamba, Jan-Willem Veening, Nigel J Saunders, Leendert W Hamoen, Richard A Daniel
Two-step assembly dynamics of the Bacillus subtilis divisome.
J Bacteriol: 2009, 191(13);4186-94
[PubMed:19429628] [WorldCat.org] [DOI] (I p)

Gonçalo Real, Allison Fay, Avigdor Eldar, Sérgio M Pinto, Adriano O Henriques, Jonathan Dworkin
Determinants for the subcellular localization and function of a nonessential SEDS protein.
J Bacteriol: 2008, 190(1);363-76
[PubMed:17981970] [WorldCat.org] [DOI] (I p)

Zuolei Lu, Michio Takeuchi, Tsutomu Sato
The LysR-type transcriptional regulator YofA controls cell division through the regulation of expression of ftsW in Bacillus subtilis.
J Bacteriol: 2007, 189(15);5642-51
[PubMed:17526699] [WorldCat.org] [DOI] (P p)