CueR

• Description: transcriptional regulator of the copZ-copA operon
  
  

Gene name	cueR
Synonyms	yhdQ
Essential	no
Product	transcriptional regulator (MerR family)
Function	regulation of the copZ-copA operon
Gene expression levels in SubtiExpress: cueR
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	16 kDa, 7.886
Gene length, protein length	429 bp, 143 aa
Immediate neighbours	yhdP, yhdR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

The gene

Basic information

• Locus tag: BSU09560

Database entries

• BsubCyc: BSU09560

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU09560

• Structure:

• UniProt: O07586

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: cueR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Nesha May Andoy, Susanta K Sarkar, Qi Wang, Debashis Panda, Jaime J Benítez, Aleksandr Kalininskiy, Peng Chen
Single-molecule study of metalloregulator CueR-DNA interactions using engineered Holliday junctions.
Biophys J: 2009, 97(3);844-52
[PubMed:19651042] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)

Ahmed Gaballa, Min Cao, John D Helmann
Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.
Microbiology (Reading): 2003, 149(Pt 12);3413-3421
[PubMed:14663075] [WorldCat.org] [DOI] (P p)