YkwC

• Description: putative beta-hydroxyacid dehydrogenase
  
  

Gene name	ykwC
Synonyms
Essential	no
Product	putative beta-hydroxyacid dehydrogenase
Function	unknown
Gene expression levels in SubtiExpress: ykwC
MW, pI	30 kDa, 5.109
Gene length, protein length	864 bp, 288 aa
Immediate neighbours	mcpC, ykwD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

poorly characterized/ putative enzymes

The gene

Basic information

• Locus tag: BSU13960

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: 3-hydroxyisobutyrate dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): YfjR

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Ser-281 by PrkC, dephosphorylated by PrpC, phosphorylation abolishes the oxidoreductase activity of YkwC in vitro and in vivo PubMed

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34948

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ykwC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Vaishnavi Ravikumar, Lei Shi, Karsten Krug, Abderahmane Derouiche, Carsten Jers, Charlotte Cousin, Ahasanul Kobir, Ivan Mijakovic, Boris Macek
Quantitative phosphoproteome analysis of Bacillus subtilis reveals novel substrates of the kinase PrkC and phosphatase PrpC.
Mol Cell Proteomics: 2014, 13(8);1965-78
[PubMed:24390483] [WorldCat.org] [DOI] (I p)