YtrA

• Description: transcriptional repressor, GntR family, control of cell envelope stress responses in response to ramoplanin
  
  

Gene name	ytrA
Synonyms
Essential	no
Product	transcriptional repressor (GntR family)
Function	control of cell envelope stress responses
Gene expression levels in SubtiExpress: ytrA
Metabolic function and regulation of this protein in SubtiPathways: ytrA
MW, pI	14 kDa, 8.094
Gene length, protein length	390 bp, 130 aa
Immediate neighbours	ytrB, ytrG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

transcription factors and their control, cold stress proteins, resistance against toxins/ antibiotics

This gene is a member of the following regulons

YtrA regulon

The gene

Basic information

• Locus tag: BSU30460

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3NEU (similar protein from Listeria innocua, 41% identity)

• UniProt: O34712

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytrG-ytrA-ytrB-ytrC-ytrD-ytrE-ytrF PubMed

• Expression browser: ytrA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by ramoplanin (YtrA) PubMed
  • expressed early in the stationary phase PubMed
  • induced by cold shock (5-fold) PubMed

• Regulatory mechanism:
  • YtrA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Carsten L Beckering, Leif Steil, Michael H W Weber, Uwe Völker, Mohamed A Marahiel
Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis.
J Bacteriol: 2002, 184(22);6395-402
[PubMed:12399512] [WorldCat.org] [DOI] (P p)

K I Yoshida, Y Fujita, S D Ehrlich
An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis.
J Bacteriol: 2000, 182(19);5454-61
[PubMed:10986249] [WorldCat.org] [DOI] (P p)