BrxB

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  • Description: bacilliredoxin

Gene name brxB
Synonyms yqiW
Essential no
Product bacilliredoxin
Function de-bacillithiolation of S-bacillithiolated OhrR and MetE
Gene expression levels in SubtiExpress: yqiW
MW, pI 16 kDa, 4.814
Gene length, protein length 435 bp, 145 aa
Immediate neighbours artP, bmrU
Sequences Protein DNA DNA_with_flanks
Genetic context
YqiW context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YqiW expression.png















Categories containing this gene/protein

membrane proteins, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU23990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: UPF0403 family (according to Swiss-Prot)
  • Paralogous protein(s): BrxA

Extended information on the protein

  • Kinetic information:
  • Domains: contains an CxC redox motif redox active Cys residue [3]
  • Modification:
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [4]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: brxB (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

YpdA, BrxA, BrxB and YtxJ cooccur in those species predicted to synthesize bacillithiol.

References

Ahmed Gaballa, Bui Khanh Chi, Alexandra A Roberts, Dörte Becher, Chris J Hamilton, Haike Antelmann, John D Helmann
Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE.
Antioxid Redox Signal: 2014, 21(3);357-67
[PubMed:24313874] [WorldCat.org] [DOI] (I p)

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)