ComP

• Description: two-component sensor kinase, detects extracellular ComX
  
  

Gene name	comP
Synonyms
Essential	no
Product	two-component sensor kinase
Function	regulation of genetic competence and quorum sensing
Gene expression levels in SubtiExpress: comP
Interactions involving this protein in SubtInteract: ComP
MW, pI	89 kDa, 7.997
Gene length, protein length	2307 bp, 769 aa
Immediate neighbours	comA, comX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, protein modification, transcription factors and their control, quorum sensing, membrane proteins, phosphoproteins

The gene

Basic information

• Locus tag: BSU31690

Phenotypes of a mutant

• the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the pgsB-pgsC-pgsA operon PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of ComA

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: eight transmembrane segments

• Modification: autophosphorylation on a His residue

• Cofactors:

• Effectors of protein activity: ComX (extracellular)

• Interactions:
  • ComP-ComA

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: Q99027

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comP PubMed

• Expression browser: comP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575] [WorldCat.org] [DOI] (P p)