DnaJ

• Description: heat-shock protein (activation of DnaK)
  
  

Gene name	dnaJ
Synonyms
Essential	no
Product	heat-shock protein (activation of DnaK)
Function	protein quality control
Gene expression levels in SubtiExpress: dnaJ
Interactions involving this protein in SubtInteract: DnaJ
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	40 kDa, 7.92
Gene length, protein length	1116 bp, 372 aa
Immediate neighbours	yqeT, surC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins

This gene is a member of the following regulons

HrcA regulon

The gene

Basic information

• Locus tag: BSU25460

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: dnaJ family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • DnaK-DnaJ

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P17631

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV PubMed

• Expression browser: dnaJ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by heat shock (HrcA) PubMed

• Regulatory mechanism:
  • HrcA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage