CsbA

• Description: general stress protein, required for protection against paraquat stress
  
  

Gene name	csbA
Synonyms
Essential	no
Product	unknown
Function	protection against paraquat stress
Gene expression levels in SubtiExpress: csbA
MW, pI	8 kDa, 9.295
Gene length, protein length	228 bp, 76 aa
Immediate neighbours	uvrB, yvkC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress, membrane proteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU35180

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P37953

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: csbA PubMed

• Expression browser: csbA PubMed

• Sigma factor: SigA PubMed, SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Alexander Reder, Dirk Höper, Ulf Gerth, Michael Hecker
Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3601-10
[PubMed:22582280] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

S A Boylan, M D Thomas, C W Price
Genetic method to identify regulons controlled by nonessential elements: isolation of a gene dependent on alternate transcription factor sigma B of Bacillus subtilis.
J Bacteriol: 1991, 173(24);7856-66
[PubMed:1744042] [WorldCat.org] [DOI] (P p)