PonA
- Description: penicillin-binding protein 1A/1B
Gene name | ponA |
Synonyms | |
Essential | no |
Product | penicillin-binding protein 1A/1B |
Function | bifunctional glucosyltransferase/ transpeptidase |
Gene expression levels in SubtiExpress: ponA | |
Interactions involving this protein in SubtInteract: PonA | |
MW, pI | 99 kDa, 4.752 |
Gene length, protein length | 2742 bp, 914 aa |
Immediate neighbours | recU, ypoC |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
cell wall synthesis, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22320
Phenotypes of a mutant
- prevents bulging of the cells when grown at low Mg(2+) concentrations, suppresses the lethal effect of a mreB mutation PubMed
- deletion of ponA restores growth and normal shape of a yvcK mutant on gluconeogenic carbon sources PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P39793
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: constitutive during vegetative growth PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jeff Errington lab
- Antibody:
Labs working on this gene/protein
Jeff Errington, Newcastle University, UK homepage
Your additional remarks
References
Reviews
Original publications