TagO

• Description: undecaprenyl-phosphate-GlcNAc-1-phosphate transferase, teichoic acid linkage unit synthesis
  
  

Gene name	tagO
Synonyms	yvhI
Essential	yes PubMed
Product	undecaprenyl-phosphate-GlcNAc-1-phosphate transferase
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: tagO
MW, pI	39 kDa, 10.424
Gene length, protein length	1074 bp, 358 aa
Immediate neighbours	tagV, tuaH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU35530

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-N-acetyl-D-glucosamine + undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-undecaprenol (according to Swiss-Prot)

• Protein family: glycosyltransferase 4 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O34753

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: tagO PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Yoshimasa Ishizaki, Chigusa Hayashi, Kunio Inoue, Masayuki Igarashi, Yoshiaki Takahashi, Venugopal Pujari, Dean C Crick, Patrick J Brennan, Akio Nomoto
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45.
J Biol Chem: 2013, 288(42);30309-30319
[PubMed:23986448] [WorldCat.org] [DOI] (I p)

Alex Formstone, Rut Carballido-López, Philippe Noirot, Jeffery Errington, Dirk-Jan Scheffers
Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis.
J Bacteriol: 2008, 190(5);1812-21
[PubMed:18156271] [WorldCat.org] [DOI] (I p)

Blazenka Soldo, Vladimir Lazarevic, Dimitri Karamata
tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168.
Microbiology (Reading): 2002, 148(Pt 7);2079-2087
[PubMed:12101296] [WorldCat.org] [DOI] (P p)