PucC

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  • Description: xanthine dehydrogenase

Gene name pucC
Synonyms yurD
Essential no
Product xanthine dehydrogenase
Function purine utilization
Gene expression levels in SubtiExpress: pucC
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine catabolism, Nucleotides (regulation)
MW, pI 29 kDa, 8.576
Gene length, protein length 831 bp, 277 aa
Immediate neighbours pucD, pucB
Sequences Protein DNA DNA_with_flanks
Genetic context
PucC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PucC expression.png




























Categories containing this gene/protein

utilization of nucleotides

This gene is a member of the following regulons

PucR regulon

The gene

Basic information

  • Locus tag: BSU32490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Xanthine + NAD+ + H2O = urate + NADH (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1JRO (from Rhodobacter capsulatus, 39% identity, 55% similarity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of purine nucleotides (effector: allantoin) (PucR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References