ComEC

• Description: channel protein for DNA binding and uptake
  
  

Gene name	comEC
Synonyms	comD
Essential	no
Product	DNA channel
Function	genetic competence
Gene expression levels in SubtiExpress: comEC
Interactions involving this protein in SubtInteract: ComEC
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Protein secretion
MW, pI	86 kDa, 6.964
Gene length, protein length	2328 bp, 776 aa
Immediate neighbours	yqzM, comEB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon, ComN regulon

The gene

Basic information

• Locus tag: BSU25570

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ComEC-ComEA PubMed
  • ComEC-ComFA PubMed
  • ComEC-ComGA PubMed

• Localization:
  • cell membrane PubMed
  • localizes to one or both cell poles PubMed

Database entries

• Structure:

• UniProt: P39695

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comEA-comEB-comEC PubMed

• Expression browser: comEC PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • post-translational control by ComN PubMed
  • yutB is required for transcription PubMed
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)