RsbRB

• Description: probably part of the stressosome
  
  

Gene name	rsbRB
Synonyms	ispU, ykoB
Essential	no
Product	RsbR paralog
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbRB
Interactions involving this protein in SubtInteract: RsbRB
MW, pI	32 kDa, 4.788
Gene length, protein length	831 bp, 277 aa
Immediate neighbours	ispA, thiX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, phosphoproteins

The gene

Basic information

• Locus tag: BSU13200

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • negative regulator of YtvA-dependent light activation of the SigB stress response PubMed

• Protein family:

• Paralogous protein(s): RsbR, RsbRC, RsbRD, YtvA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Thr-186 and probably also on Thr-220 by RsbT PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbRB-RsbT PubMed
  • component of the stressosome

• Localization:

Database entries

• Structure:

• UniProt: O34860

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: rsbRB PubMed

• Sigma factor:

• Regulation: constitutively expressed PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Adam Reeves, Luis Martinez, William Haldenwang
Expression of, and in vivo stressosome formation by, single members of the RsbR protein family in Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 4);990-998
[PubMed:20019076] [WorldCat.org] [DOI] (I p)

Christine Eymann, Dörte Becher, Jörg Bernhardt, Katrin Gronau, Anja Klutzny, Michael Hecker
Dynamics of protein phosphorylation on Ser/Thr/Tyr in Bacillus subtilis.
Proteomics: 2007, 7(19);3509-26
[PubMed:17726680] [WorldCat.org] [DOI] (P p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

Tae-Jong Kim, Tatiana A Gaidenko, Chester W Price
A multicomponent protein complex mediates environmental stress signaling in Bacillus subtilis.
J Mol Biol: 2004, 341(1);135-50
[PubMed:15312768] [WorldCat.org] [DOI] (P p)