GlpQ

• Description: glycerolphosphate diester phosphodiesterase
  
  

Gene name	glpQ
Synonyms	ybeD
Essential	no
Product	glycerolphosphate diester phosphodiesterase
Function	glycerol-3-phosphate utilization
Gene expression levels in SubtiExpress: glpQ
MW, pI	32 kDa, 9.263
Gene length, protein length	879 bp, 293 aa
Immediate neighbours	ybeC, glpT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, utilization of lipids

This gene is a member of the following regulons

CcpA regulon, GlpP regulon, PhoP regulon

The gene

Basic information

• Locus tag: BSU02130

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: A glycerophosphodiester + H₂O = an alcohol + sn-glycerol 3-phosphate (according to Swiss-Prot)

• Protein family: glycerophosphoryl diester phosphodiesterase family (according to Swiss-Prot)

• Paralogous protein(s): YhdW, YqiK

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 2PZ0 (the enzyme from Thermoanaerobacter tengcongensis) PubMed

• UniProt: P37965

• KEGG entry: [3]

• E.C. number: 3.1.4.46

Expression and regulation

• Operon:
  • glpT-glpQ PubMed
  • glpQ

• Expression browser: glpQ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (6.2-fold) (CcpA) PubMed
  • induced by glycerol (GlpP) PubMed
  • glpQ: induced by phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression
  • GlpP: transcriptional antitermination via a protein-dependent RNA switch
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: