ClsA

• Description: cardiolipin synthase, major enzyme
  
  

Gene name	clsA
Synonyms	ywnE
Essential	no
Product	cardiolipin synthase, major enzyme
Function	biosynthesis of phospholipids
Gene expression levels in SubtiExpress: clsA
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	55 kDa, 9.554
Gene length, protein length	1446 bp, 482 aa
Immediate neighbours	ywnF, mta
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, membrane proteins

The gene

Basic information

• Locus tag: BSU36590

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol (according to Swiss-Prot)

• Protein family: Cardiolipin synthase subfamily (according to Swiss-Prot)

• Paralogous protein(s): YwiE, YwjE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane at the septum PubMed

Database entries

• Structure:

• UniProt: P71040

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: clsA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Letal I Salzberg, John D Helmann
Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition.
J Bacteriol: 2008, 190(23);7797-807
[PubMed:18820022] [WorldCat.org] [DOI] (I p)

Claudia S López, Alejandro F Alice, Horacio Heras, Emilio A Rivas, Carmen Sánchez-Rivas
Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity.
Microbiology (Reading): 2006, 152(Pt 3);605-616
[PubMed:16514141] [WorldCat.org] [DOI] (P p)

Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965] [WorldCat.org] [DOI] (P p)

Fumitaka Kawai, Momoko Shoda, Rie Harashima, Yoshito Sadaie, Hiroshi Hara, Kouji Matsumoto
Cardiolipin domains in Bacillus subtilis marburg membranes.
J Bacteriol: 2004, 186(5);1475-83
[PubMed:14973018] [WorldCat.org] [DOI] (P p)