ArgG

• Description: argininosuccinate synthase, reversible
  
  

Gene name	argG
Synonyms
Essential	no
Product	argininosuccinate synthase, reversible
Function	biosynthesis of arginine
Gene expression levels in SubtiExpress: argG
Metabolic function and regulation of this protein in SubtiPathways: Ammonium/ glutamate
MW, pI	44 kDa, 5.028
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	argH, moaB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, phosphoproteins

This gene is a member of the following regulons

AhrC regulon

The gene

Basic information

• Locus tag: BSU29450

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate (according to Swiss-Prot)

• Protein family: Type 1 subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • S-cysteinylation after diamide stress (C187) PubMed
  • phosphorylated on Arg-262 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1KH1 (from Thermus thermophilus, 44% identity, 65% similarity) PubMed

• UniProt: O34347

• KEGG entry: [2]

• E.C. number: 6.3.4.5

Expression and regulation

• Operon: argG-argH PubMed

• Expression browser: argG PubMed

• Sigma factor:

• Regulation:
  • repressed by casamino acids PubMed
  • repressed by arginine (AhrC)

• Regulatory mechanism:
  • AhrC: transcription repression

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: