EfeB

• Description: elemental iron uptake system (binding protein)
  
  

Gene name	ywbN
Synonyms	ipa-29d
Essential	no
Product	elemental iron uptake system (binding protein)
Function	iron uptake
Gene expression levels in SubtiExpress: ywbN
Interactions involving this protein in SubtInteract: YwbN
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	45 kDa, 8.64
Gene length, protein length	1248 bp, 416 aa
Immediate neighbours	ywbO, ywbM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, acquisition of iron, iron metabolism, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

Fur regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU38260

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: DyP-type peroxidase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (YwbL-YwbM)-YwbN PubMed

• Localization:
  • extracellular, secreted by the TatAY-TatCY complex PubMed
  • TatAY-TatCY-dependent export of YwbN requires a functional WprA PubMed
  • forms a membrane-bound complex with YwbM and YwbL for iron uptake PubMed

Database entries

• Structure:

• UniProt: P39597

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • ywbL-ywbM-ywbN PubMed
  • ywbN-ywbO PubMed

• Expression browser: ywbN PubMed

• Sigma factor:
  • ywbN: SigM PubMed, SigX, SigW PubMed

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands