MetQ

• Description: methionine ABC transporter (binding lipoprotein)
  
  

Gene name	metQ
Synonyms	yusA
Essential	no
Product	methionine ABC transporter (binding lipoprotein)
Function	methionine uptake
Gene expression levels in SubtiExpress: metQ
Interactions involving this protein in SubtInteract: MetQ
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	30 kDa, 8.493
Gene length, protein length	822 bp, 274 aa
Immediate neighbours	yurZ, metP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, S-box

The gene

Basic information

• Locus tag: BSU32730

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YhcJ

Extended information on the protein

• Kinetic information:
  • K(D) for Met: 3.8 myM PubMed

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • MetN-MetP-MetQ PubMed
  • McpC-MetQ, for chemotaxis to methionine PubMed

• Localization:
  • associated to the cell membrane, via MetP PubMed
  • extracellular (signal peptide) PubMed, lipid modification as retention signal

Database entries

• Structure:

• UniProt: O32167

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: metN-metP-metQ PubMed

• Expression browser: metQ PubMed

• Sigma factor:

• Regulation:
  • activated during growth in the presence of branched chain amino acids (CodY) PubMed
  • induced by methionine starvation (S-box) PubMed

• Regulatory mechanism:
  • S-box: transcription termination/ antitermination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed
  • CodY: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: