SftA

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  • Description: DNA translocase

Gene name sftA
Synonyms ytpS, cdtA
Essential no
Product DNA translocase
Function resolution of chromosome dimers
Gene expression levels in SubtiExpress: sftA
MW, pI 107 kDa, 5.052
Gene length, protein length 2856 bp, 952 aa
Immediate neighbours murC, ytpR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YtpS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SftA expression.png
























Categories containing this gene/protein

DNA condensation/ segregation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29805

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • aids in moving DNA away from the closing septum, binds DNA, DNA-dependent ATPase activity PubMed
    • the two DNA translocases SftA and SpoIIIE synergistically affect chromosome dimer resolution presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively PubMed
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950] [WorldCat.org] [DOI] (I p)

Original publications