CotB

• Description: spore coat protein (outer)
  
  

Gene name	cotB
Synonyms
Essential	no
Product	spore coat protein (outer)
Function	resistance of the spore
Gene expression levels in SubtiExpress: cotB
Interactions involving this protein in SubtInteract: CotB
MW, pI	42 kDa, 9.831
Gene length, protein length	1140 bp, 380 aa
Immediate neighbours	ywrJ, cotH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

GerE regulon, GerR regulon, SigK regulon

The gene

Basic information

• Locus tag: BSU36050

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • CotB-CotG PubMed

• Localization:
  • outer spore coat, at the middle of the spore as a ring- or spiral-like structure PubMed

Database entries

• Structure:

• UniProt: P07789

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: cotB PubMed

• Sigma factor: SigK PubMed

• Regulation:
  • expressed late during sporulation in the mother cell (SigK, GerE, GerR) PubMed

• Regulatory mechanism:
  • GerE: transcription activation PubMed
  • GerR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:
  • 1S102 ( cotB::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: