CsoR

• Description: transcription repressor of copZ-copA
  
  

Gene name	csoR
Synonyms	yvgZ
Essential	no
Product	transcription repressor
Function	control of copper homeostasis
Gene expression levels in SubtiExpress: csoR
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	11 kDa, 7.299
Gene length, protein length	303 bp, 101 aa
Immediate neighbours	copZ, yvaA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

The CsoR regulon:

• copZ-copA, yotD

The gene

Basic information

• Locus tag: BSU33520

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: Cu(I) ions cause release of CsoR from its operator sites

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32222

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: csoR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Mohamed Marahiel, Marburg University, Germany homepage

References

Reviews

Corinna Rademacher, Bernd Masepohl
Copper-responsive gene regulation in bacteria.
Microbiology (Reading): 2012, 158(Pt 10);2451-2464
[PubMed:22918892] [WorldCat.org] [DOI] (I p)