UppS

• Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
  
  

Gene name	uppS
Synonyms	yluA
Essential	yes PubMed
Product	undecaprenyl pyrophosphate synthetase
Function	cell wall biosynthesis
Gene expression levels in SubtiExpress: uppS
MW, pI	29 kDa, 5.408
Gene length, protein length	780 bp, 260 aa
Immediate neighbours	frr, cdsA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of lipids, essential genes

The gene

Basic information

• Locus tag: BSU16530

Phenotypes of a mutant

• essential PubMed
• the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed=== Database entries ===

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate

• Protein family: UPP synthetase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31751

• KEGG entry: [2]

• E.C. number: 2.5.1.31

Expression and regulation

• Operon:

• Expression browser: uppS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: