UppS

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  • Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

Gene name uppS
Synonyms yluA
Essential yes PubMed
Product undecaprenyl pyrophosphate synthetase
Function cell wall biosynthesis
Gene expression levels in SubtiExpress: uppS
MW, pI 29 kDa, 5.408
Gene length, protein length 780 bp, 260 aa
Immediate neighbours frr, cdsA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
UppS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
UppS expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of lipids, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU16530

Phenotypes of a mutant

  • essential PubMed
  • the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed=== Database entries ===
  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
  • Protein family: UPP synthetase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References