Drm

• Description: phosphopentomutase
  
  

Gene name	drm
Synonyms	yqkN
Essential	no
Product	phosphopentomutase
Function	utilization of deoxyribose
Gene expression levels in SubtiExpress: drm
Metabolic function and regulation of this protein in SubtiPathways: Nucleoside catabolism, Nucleotides (regulation)
MW, pI	43 kDa, 4.974
Gene length, protein length	1182 bp, 394 aa
Immediate neighbours	pupG, ripX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nucleotides, phosphoproteins

This gene is a member of the following regulons

CcpA regulon

The gene

Basic information

• Locus tag: BSU23500

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate (according to Swiss-Prot)

• Protein family: phosphopentomutase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on (Thr-87 OR Thr-89) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3M8W (from B. cereus, 77% identity, 86% similarity) PubMed

• UniProt: P46353

• KEGG entry: [3]

• E.C. number: 5.4.2.7

Expression and regulation

• Operon: drm-pupG PubMed

• Expression browser: drm PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) PubMed
  • subject to carbon catabolite repression (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed