YaaO

Gene name	yaaO
Synonyms
Essential	no
Product	carboxynorspermidine decarboxylase
Function	synthesis of norspermidine
Gene expression levels in SubtiExpress: yaaO
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation)
MW, pI	52 kDa, 5.713
Gene length, protein length	1440 bp, 480 aa
Immediate neighbours	yaaN, tmk
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biofilm formation

The gene

Basic information

• Locus tag: BSU00270

Phenotypes of a mutant

• • impaired biofilm disassembly PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • catalyzes the last step in norspermidine synthesis PubMed

• Protein family: Orn/Lys/Arg decarboxylase class-I family (according to Swiss-Prot)

• Paralogous protein(s): SpeA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P37536

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yaaO PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ilana Kolodkin-Gal, Shugeng Cao, Liraz Chai, Thomas Böttcher, Roberto Kolter, Jon Clardy, Richard Losick
A self-produced trigger for biofilm disassembly that targets exopolysaccharide.
Cell: 2012, 149(3);684-92
[PubMed:22541437] [WorldCat.org] [DOI] (I p)

Matthew Burrell, Colin C Hanfrey, Ewan J Murray, Nicola R Stanley-Wall, Anthony J Michael
Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation.
J Biol Chem: 2010, 285(50);39224-38
[PubMed:20876533] [WorldCat.org] [DOI] (I p)