YncD

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  • Description: alanine racemase

Gene name yncD
Synonyms alrB
Essential no
Product alanine racemase
Function unknown
Metabolic function and regulation of this protein in SubtiPathways:
Alternative nitrogen sources
MW, pI 43 kDa, 9.593
Gene length, protein length 1182 bp, 394 aa
Immediate neighbours yncC, yncE
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YncD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YncD expression.png
























Categories containing this gene/protein

sporulation proteins, poorly characterized/ putative enzymes

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

  • Locus tag: BSU17640

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-alanine = D-alanine (according to Swiss-Prot)
  • Protein family: alanine racemase family (according to Swiss-Prot)
  • Paralogous protein(s): Alr

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon: yncD (according to DBTBS)
  • Regulation:
    • expressed during sporulation in the mother cell (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Kara J Pierce, Samson P Salifu, Martin Tangney
Gene cloning and characterization of a second alanine racemase from Bacillus subtilis encoded by yncD.
FEMS Microbiol Lett: 2008, 283(1);69-74
[PubMed:18399999] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Andrea Feucht, Louise Evans, Jeff Errington
Identification of sporulation genes by genome-wide analysis of the sigmaE regulon of Bacillus subtilis.
Microbiology (Reading): 2003, 149(Pt 10);3023-3034
[PubMed:14523133] [WorldCat.org] [DOI] (P p)