Program

Tuesday April 24th 2012 – Morning

• 8:00-8:45 - REGISTRATION
• 9:00-9:10 – Welcome Introduction Kevin Devine

Session I: Modeling and Networks

CHAIR: Sierd Bron

• 9:10-9:30 – BACELL Systems – Past, Present, Future
  • Jan Maarten van Dijl (University Medical Center Groningen)

• 9:30-9:50 – Unraveling the Small Regulatory RNA Network of Bacillus subtilis
  • Ruben Mars (University Medical Center Groningen)

• 9:50-10:10 – A Computational Stressosome Model Consolidates Hypotheses about Environmental Activation of SigB the General Stress response
  • Ulf Liebal (University of Rostock)

• 10:10-10:30 – Reconciling Molecular Regulatory Mechanisms with Noise Patterns of Bacterial Metabolic Promoters in Induced and Repressed States
  • Matthieu Jules (Institut Micalis, INRA)

• 10:30 – 11:00 – COFFEE BREAK

Session II: Cell Wall

CHAIR: Colin Harwood

• 11:00-11:20 – The WalR/WalK, PhoP/PhoR and SigI/RsgI Regulatory Systems of Bacillus subtilis Cooperate to Control Cell Wall Metabolism during Growth and Under Stress Conditions
  • Letal Salzberg (Trinity College Dublin)

• 11:20-11:40 – Adaptation of Bacillus subtilis to High Salinity: Osmotic Induction of the Cell Wall Hydrolase YqiI
  • Kathleen Fischer (Philipps-Universität Marburg)

• 11:40-12:00 – Regulatory and Cellular Dynamics of the Lia-Response of Bacillus subtilis
  • Thorsten Mascher (Ludwig-Maximilians-University Munich)

• 12:00-12:20 – SepF is a New Membrane Anchor for the Key Cell Division Protein FtsZ
  • Ilkay Celik (Newcastle University)

• 12:20-12:40 – The Bacterial MreB Cytoskeleton Organizes the Cell Membrane
  • Henrik Strahl (Newcastle University)

• 12:40 – 14:20 LUNCH (+ BACIP MEETING)

Tuesday April 24th 2012 – Afternoon

Session III: Adaptation, Sporulation and DNA Replication

CHAIR: Ulrike Mäder

• 14:20-14:40 – Selecting Better Bet Hedging Bacillus Strains
  • Jeroen Siebring (University of Groningen)

• 14:40-15:00 – Spore Coat Proteins: Self-Assembly Properties and Protein-Protein Interactions
  • Daniela Krajčíková (Slovak Academy of Sciences)

• 15:00-15:20 – Spo0A links DNA Replication with Sporulation by Direct Binding to the Origin of Replication in Bacillus subtilis
  • Mirjam Boonstra (University of Groningen)

• • 15:20-15:40 – DSB Repair Pathway is Required for Viability of the SMC-ScpA-ScpB Depleted Strain
  • Etienne Dervyn (Institut Micalis, INRA)

• 15:40-16:10 - COFFEE BREAK

Session IV: Antibiotics

CHAIR: Eugenio Ferrari

• 16:10-16:30 – Regulated Expression of a Multidrug-ABC Transporter – The yheH-yheI-yheJ Operon
  • Ewoud Reilman (University of Groningen)

• 16:30-16:50 – Signal Transduction in Antimicrobial Peptide Detoxification Modules of Bacillus subtilis: Interaction between ABC Transport and Sensor Kinase
  • Susanne Gebhard (Ludwig-Maximilians-University Munich)

• 16:50-17:10 – Structure-Function Relationship of the Lantibiotic Immunity-Protein SpaI
  • Sophie Bochmann (Goethe University Frankfurt)

• 17:10-17:30 – Structure, Biosynthesis and Properties of Kurstakins, Nonribosomal Lipopeptides from Bacillus spp.
  • Philippe Jacques (Universite de Lille)

Wednesday April 25th 2012 - Morning

Session V: Application

CHAIR: Jörg Stülke

• 9:00-9:20 – Bacillus subtilis Cell Factory Producing Scyllo-Inositol, A Potential Therapeutic Agent for Alzheimer’s Disease
  • Ken-ichi Yoshida (Kobe University)

• 9:20-9:40 – Developing an Enzyme Discovery Tool for Bacillus subtilis
  • Tjeerd van Rij (DSM)

• 9:40 – 10:00 - Use of Bacillus amyloliquefaciens for Control of Plant Stress
  • Johan Meijer (University of Uppsala)

• 10:00 – 10:20 – Phenotypic Heterogeneity during Heterologous Protein Production in Bacillus megaterium
  • Rebekka Biedendieck (Technische Universität Braunschweig)

• 10:20-10:40 – Absolute Protein Quantification - Application in Bacillus subtilis
  • Dörte Becher (Ernst-Moritz-Arndt Universität Greifswald)

10:40-11:00 - COFFEE BREAK

Session VI: RNA Metabolism and Regulation

CHAIR: Uwe Völker

• 11:00-11:20 – Three Essential Ribonucleases RNase Y, J1 and III Control the Abundance of a Majority of B. subtilis mRNAs
  • Ciarán Condon (Institut de Biologie Physico-Chimique CNRS)

• 11:20-11:40 – The Effects of RpoE and HelD on RNA Polymerase from Bacillus subtilis
  • Libor Krásný (Academy of Sciences of the Czech Republic)

• 11:40 – 12:00 – Dynamic Localization of an RNA-Binding Transcription Factor in Bacillus subtilis
  • Fabian Rothe (University of Göttingen)

• 12:00 – 12:20 – Requirements for the High-Frequency Activation of the Cryptic gudB Glutamate Dehydrogenase Gene in Bacillus subtilis
  • Fabian Commichau (Georg-August-Universität Göttingen)

• 12:20-12:40 – The Anaerobic Formation of Acetoin Regulated by the Transcriptional Regulator AlsR – Part of pH Homeostasis in Bacillus subtilis
  • Elisabeth Härtig (TU Braunschweig)

12:40-14:00 – LUNCH

Wednesday April 25th 2012 - Afternoon

EU BaSynthec Synthetic Biology Symposium

CHAIR: Kevin Devine

• 14:00-14:10 – Introduction – Philippe Noirot (INRA)
• 14:10-14:40 – Enhanced Recombinant Protein Productivity by Genome Reduction in Bacillus subtilis - Naotake Ogasawara (Nara Institute)
• 14:40-15:10 – Computational and Bioinformatics Approaches to Enabling Synthetic Biology - Anil Wipat (Newcastle University)
• 15:10-15:40 – Highly Modified Peptides by Synthetic Biology Approaches - Oscar Kuipers (Groningen University)

• 15:40-16:10 – COFFEE BREAK

• 16:10-16:40 – Bacillus subtilis Minimal Genome Work in Europe - Philippe Noirot (INRA)
• 16:40-17:10 – View of Novozymes on Synthetic Biology - Allen Kent Nielsen (Novozymes)
• 17:10-17:40 – View of DSM on Synthetic Biology - Zoltán Prágai (DSM)
• 17:40-17:50 – Wrap up / end of workshop – Philippe Noirot (INRA)