CatR

• Description: MarR/DUF24-family transcription repressor of the catD-catE operon
  
  

Gene name	catR
Synonyms	yvaP
Essential	no
Product	MarR/DUF24-family transcription repressor
Function	Resistance against oxidative and electrophile stress
MW, pI	26 kDa, 9.887
Gene length, protein length	708 bp, 236 aa
Immediate neighbours	yvaO, yvaQ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The CatR regulon:

catD-catE

The gene

Basic information

• Locus tag: BSU33680

Phenotypes of a mutant

increased resistance to catechol and quinones PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: MarR/DUF24-family transcription repressor of the catD-catE operon PubMed

• Protein family:

• Paralogous protein(s): YodB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of catD-catE) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32238

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed