YpbH

• Description: putative adaptor protein
  
  

Gene name	ypbH
Synonyms
Essential	no
Product	putative adaptor protein
Function	unknown
Interactions involving this protein in SubtInteract: YpbH
MW, pI	22 kDa, 4.095
Gene length, protein length	582 bp, 194 aa
Immediate neighbours	gudB, ypbG
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

proteolysis

The gene

Basic information

• Locus tag: BSU22970

Phenotypes of a mutant

deletion reduces sporulation to 20%, overexpression abolishes sporulation PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): MecA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YpbH-ClpC PubMed

• Localization:

Database entries

• Structure: 3JTO (C-terminal domain) PubMed

• UniProt: P50734

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • low expression, enhanced in stat phase in LB or competence but not in sporulation medium PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: GP812 (spc), GP814 (spc) both available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260] [WorldCat.org] [DOI] (I p)

Original Publications

Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Siheng Xiang, Zhiyuan Zhou, Qi Hu, Jiawei Wang, Yigong Shi
Crystal structure of the MecA degradation tag.
J Biol Chem: 2009, 284(49);34376-81
[PubMed:19801546] [WorldCat.org] [DOI] (I p)

Marjan Persuh, Ines Mandic-Mulec, David Dubnau
A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
J Bacteriol: 2002, 184(8);2310-3
[PubMed:11914365] [WorldCat.org] [DOI] (P p)