AseR

• Description: transcriptional repressor of aseA and aseR
  
  

Gene name	aseR
Synonyms	ydeT
Essential	no
Product	transcriptional repressor (ArsR family)
Function	regulation of As (III) efflux
MW, pI	12 kDa, 6.307
Gene length, protein length	333 bp, 111 aa
Immediate neighbours	ydeS, aseA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

AseR regulon

The AseR regulon:

• aseA, aseR

The gene

Basic information

• Locus tag: BSU05330

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: As(III) acts as molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P96677

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • induced by As(III) (AseR) PubMed

• Regulatory mechanism:
  • AseR: transcription repression (autorepression) PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Duncan R Harvie, Claudia Andreini, Gabriele Cavallaro, Wenmao Meng, Bernard A Connolly, Ken-ichi Yoshida, Yasutaro Fujita, Colin R Harwood, David S Radford, Stephen Tottey, Jennifer S Cavet, Nigel J Robinson
Predicting metals sensed by ArsR-SmtB repressors: allosteric interference by a non-effector metal.
Mol Microbiol: 2006, 59(4);1341-56
[PubMed:16430705] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)