MscL
- Description: large conductance mechanosensitive channel protein, prevents selective release of cytoplasmic proteins in a hypotonic environment
Gene name | mscL |
Synonyms | ywpC |
Essential | no |
Product | large conductance mechanosensitive channel protein |
Function | resistance to osmotic downshockglycine betaine export |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 14 kDa, 4.649 |
Gene length, protein length | 390 bp, 130 aa |
Immediate neighbours | ywpD, ywpB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
coping with hypo-osmotic stress, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU36360
Phenotypes of a mutant
sensitive to osmotic downshock (> 0.5 M) during logarithmic growth PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: mscL family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane PubMed
Database entries
- UniProt: P94585
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mscL PubMed
- Regulation: expressed in logarithmic phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Jan Maarten van Dijl, Groningen, Netherlands
Erhard Bremer, University of Marburg, Germany homepage
Your additional remarks
References
Reviews
Ching Kung, Boris Martinac, Sergei Sukharev
Mechanosensitive channels in microbes.
Annu Rev Microbiol: 2010, 64;313-29
[PubMed:20825352]
[WorldCat.org]
[DOI]
(I p)
Valeria Vásquez, Eduardo Perozo
Structural biology: A channel with a twist.
Nature: 2009, 461(7260);47-9
[PubMed:19727188]
[WorldCat.org]
[DOI]
(I p)
Christopher D Pivetti, Ming-Ren Yen, Samantha Miller, Wolfgang Busch, Yi-Hsiung Tseng, Ian R Booth, Milton H Saier
Two families of mechanosensitive channel proteins.
Microbiol Mol Biol Rev: 2003, 67(1);66-85, table of contents
[PubMed:12626684]
[WorldCat.org]
[DOI]
(P p)
Original Publications