MetA

• Description: homoserine O-succinyltransferase
  
  

Gene name	metA
Synonyms	metB
Essential	no
Product	homoserine O-succinyltransferase
Function	biosynthesis of methionine
Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr, Cys, Met & Sulfate assimilation
MW, pI	25 kDa, 6.414
Gene length, protein length	672 bp, 224 aa
Immediate neighbours	bsaA, ugtP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids cell envelope stress proteins (controlled by SigM, W, X, Y)

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

• Locus tag: BSU21910

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine (according to Swiss-Prot) O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2GHR (from Bacillus cereus, 60% identity, 77% similarity) PubMed

• UniProt: P54167

• KEGG entry: [3]

• E.C. number: 2.3.1.46 8 2.5.1.48]

Expression and regulation

• Operon: metA (according to DBTBS)

• Sigma factor: SigM PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: