YxdL

• Description: ABC transporter (ATP-binding protein)
  
  

Gene name	yxdL
Synonyms
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	export of toxic peptides
MW, pI	28 kDa, 7.365
Gene length, protein length	771 bp, 257 aa
Immediate neighbours	yxdM, yxdK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

YxdJ regulon

The gene

Basic information

• Locus tag: BSU39640

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YxdL-YxdM PubMed

• Localization: membrane associated (via YxdM) PubMed

Database entries

• Structure:

• UniProt: P42423

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yxdL-yxdM-yxeA PubMed

• Sigma factor:

• Regulation:
  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) 21078927 PubMed

• Regulatory mechanism:
  • YxdJ: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Hanne-Leena Hyyryläinen, Milla Pietiäinen, Tuula Lundén, Anna Ekman, Marika Gardemeister, Sanna Murtomäki-Repo, Haike Antelmann, Michael Hecker, Leena Valmu, Matti Sarvas, Vesa P Kontinen
The density of negative charge in the cell wall influences two-component signal transduction in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 7);2126-2136
[PubMed:17600057] [WorldCat.org] [DOI] (P p)

Pascale Joseph, Annick Guiseppi, Alexei Sorokin, François Denizot
Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM.
Microbiology (Reading): 2004, 150(Pt 8);2609-2617
[PubMed:15289557] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)