YtaG

• Description: dephospho-CoA kinase
  
  

Gene name	ytaG
Synonyms	coaE
Essential	yes PubMed
Product	dephospho-CoA kinase
Function	synthesis of coenzyme A
Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A
MW, pI	21 kDa, 4.858
Gene length, protein length	591 bp, 197 aa
Immediate neighbours	ytbE, ytaF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of cofactors, essential genes, phosphoproteins

The gene

Basic information

• Locus tag: BSU29060

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + 3'-dephospho-CoA = ADP + CoA (according to Swiss-Prot)

• Protein family: coaE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1N3B (from Escherichia coli, 40% identity, 60% similarity) PubMed

• UniProt: O34932

• KEGG entry: [3]

• E.C. number: 2.7.1.24

Expression and regulation

• Operon: ytaG PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Alain Lévine, Françoise Vannier, Cédric Absalon, Lauriane Kuhn, Peter Jackson, Elaine Scrivener, Valérie Labas, Joëlle Vinh, Patrick Courtney, Jérôme Garin, Simone J Séror
Analysis of the dynamic Bacillus subtilis Ser/Thr/Tyr phosphoproteome implicated in a wide variety of cellular processes.
Proteomics: 2006, 6(7);2157-73
[PubMed:16493705] [WorldCat.org] [DOI] (P p)

Alia Lapidus, Nathalie Galleron, Alexei Sorokin, S Dusko Ehrlich
Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.
Microbiology (Reading): 1997, 143 ( Pt 11);3431-3441
[PubMed:9387221] [WorldCat.org] [DOI] (P p)