CarA

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  • Description: carbamoyl-phosphate transferase-arginine (subunit A)

Gene name carA
Synonyms cpa
Essential no
Product carbamoyl-phosphate transferase-arginine (subunit A)
Function biosynthesis of arginine
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Ammonium/ glutamate
MW, pI 38 kDa, 6.212
Gene length, protein length 1059 bp, 353 aa
Immediate neighbours argD, carB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CarA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

AhrC regulon

The gene

Basic information

  • Locus tag: BSU11230

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate (according to Swiss-Prot)
  • Protein family: glutamine amidotransferase type-1 domain (according to Swiss-Prot)
  • Paralogous protein(s): PyrAA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1JDB (from Escherichia coli, 47% identity, 64% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References