PsdS

• Description: two-component sensor kinase, control of psdA-psdB in response to lipid II-binding lantibiotics, such as nisin and gallidermin
  
  

Gene name	psdS
Synonyms	yvcQ
Essential	no
Product	two-component sensor kinase
Function	resistance against toxic peptides
MW, pI	40 kDa, 7.358
Gene length, protein length	1068 bp, 356 aa
Immediate neighbours	psdA, psdR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU34710

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of PsdR

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: PsdR-PsdS

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O06979

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: psdR-psdS-psdA-psdB PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: