MrgA

• Description: iron storage protein, DNA-binding stress protein, forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
  
  

Gene name	mrgA
Synonyms
Essential	no
Product	mini-ferritin, DNA-binding stress protein
Function	iron storage, protection against oxidative stress
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	17 kDa, 4.597
Gene length, protein length	459 bp, 153 aa
Immediate neighbours	yusZ, htrB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU32990

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

acquisition of iron, iron metabolism, resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing

• Protein family: dps family (according to Swiss-Prot)

• Paralogous protein(s): Dps

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): contains an iron-sulfur cluster

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2CHP

• UniProt: P37960

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mrgA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by hydrogen peroxide (PerR) PubMed

• Regulatory mechanism:
  • PerR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Emilia Chiancone, Pierpaolo Ceci, Andrea Ilari, Frederica Ribacchi, Simonetta Stefanini
Iron and proteins for iron storage and detoxification.
Biometals: 2004, 17(3);197-202
[PubMed:15222465] [WorldCat.org] [DOI] (P p)