MreBH

• Description: cell-shape determining protein, forms filaments
  
  

Gene name	mreBH
Synonyms
Essential	no
Product	cell-shape determining protein
Function	cell-shape determation
MW, pI	35 kDa, 5.239
Gene length, protein length	1005 bp, 335 aa
Immediate neighbours	ykpC, abh
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU14470

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

cell shape, heat shock proteins, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • forms ring-shaped filaments in a heterologous system PubMed

• Protein family: ftsA/mreB family (according to Swiss-Prot)

• Paralogous protein(s): MreB, Mbl

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MreBH-LytE PubMed, MreBH-Mbl, MreB-MreBH PubMed

• Localization:
  • forms helical structures close to the inner surface of the cytoplasmic membrane PubMed
  • formation of helical clusters depends on the proton motive force PubMed

Database entries

• Structure:

• UniProt: P39763

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor: SigI PubMed

• Regulation: induced by heat (SigI) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Peter Graumann, Freiburg University, Germany homepage

References

Localization

Henrik Strahl, Leendert W Hamoen
Membrane potential is important for bacterial cell division.
Proc Natl Acad Sci U S A: 2010, 107(27);12281-6
[PubMed:20566861] [WorldCat.org] [DOI] (I p)

Hervé Joël Defeu Soufo, Peter L Graumann
Dynamic localization and interaction with other Bacillus subtilis actin-like proteins are important for the function of MreB.
Mol Microbiol: 2006, 62(5);1340-56
[PubMed:17064365] [WorldCat.org] [DOI] (P p)