LctP

• Description: lactate permease, excretion
  
  

Gene name	lctP
Synonyms	ycgC
Essential	no
Product	L-lactate permease
Function	lactate excretion
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	57 kDa, 9.766
Gene length, protein length	1623 bp, 541 aa
Immediate neighbours	ldh, mdr
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU03060

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

transporters/ other, carbon core metabolism, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: lactate permease family (according to Swiss-Prot)

• Paralogous protein(s): LutP

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P55910

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ldh-lctP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced under anaerobic conditions (Rex) PubMed

• Regulatory mechanism:
  • Rex: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, T Hoffmann, M Marino, H Nedjari, E Presecan-Siedel, O Dreesen, P Glaser, D Jahn
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression.
J Bacteriol: 2000, 182(11);3072-80
[PubMed:10809684] [WorldCat.org] [DOI] (P p)