HemE

• Description: uroporphyrinogen decarboxylase (uroporphyrinogen III)
  
  

Gene name	hemE
Synonyms
Essential	no
Product	uroporphyrinogen decarboxylase (uroporphyrinogen III)
Function	heme biosynthesis
MW, pI	39 kDa, 5.262
Gene length, protein length	1059 bp, 353 aa
Immediate neighbours	pbpF, hemH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU10120

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

biosynthesis of cofactors

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Uroporphyrinogen III = coproporphyrinogen + 4 CO₂ (according to Swiss-Prot)

• Protein family: uroporphyrinogen decarboxylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2INF

• UniProt: P32395

• KEGG entry: [3]

• E.C. number: 4.1.1.37

Expression and regulation

• Operon: hemE-hemH-hemY PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

M Hansson, L Hederstedt
Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.
J Bacteriol: 1992, 174(24);8081-93
[PubMed:1459957] [WorldCat.org] [DOI] (P p)