ComP

• Description: two-component sensor kinase, detects extracellular ComX
  
  

Gene name	comP
Synonyms
Essential	no
Product	two-component sensor kinase
Function	regulation of genetic competence and quorum sensing
MW, pI	89 kDa, 7.997
Gene length, protein length	2307 bp, 769 aa
Immediate neighbours	comA, comX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU31690

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

genetic competence, protein modification, transcription factors and their control, quorum sensing, membrane proteins, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of ComA

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: eight transmembrane segments

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity: ComX (extracellular)

• Interactions: ComP-ComA

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q99027

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575] [WorldCat.org] [DOI] (P p)