QdoI

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• Description: Fe-containing quercetin 2,3-dioxygenase <br/><br/>

Gene name	qdoI
Synonyms	yxaG
Essential	no
Product	Fe-containing quercetin 2,3-dioxygenase
Function	resistance to plant product quercetin
MW, pI	37,4 kDa, 5.562
Gene length, protein length	1011 bp, 337 aa
Immediate neighbours	yxaH, yxaF
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/>

The gene

Basic information

• Locus tag: BSU39980

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Quercetin + O₂ = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H⁺ (according to Swiss-Prot)

• Protein family:bicupin family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): Fe(2+)

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2H0V

• UniProt: P42106

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: qdoI-yxaH PubMed

• Sigma factor:

• Regulation:
  • induced by flavonoids such as quercetin (YxaF, LmrA) PubMed

• Regulatory mechanism:
  • LmrA: transcription repression PubMed
  • YxaF: transcription repression PubMed

• Additional information:
  • major regulator: YxaF PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>17483215,14741339,,17483215,15317768,10746760, 20460727,14697267,, </pubmed>