cypC

cypC
168

long chain-fatty acid beta-hydroxylating cytochrome P450, H(2)O(2)-dependent, hydroxylates myristic acid to beta-hydroxymyristic acid, required for protection against paraquat stress

Locus
BSU_02100
Molecular weight
47.95 kDa
Isoelectric point
6.47
Protein length
Gene length
Function
biosynthesis of beta-hydroxy fatty acid for lipopeptides
Product
fatty acid beta-hydroxylating cytochrome P450, protection against paraquat stress
Essential
no
E.C.
null
Synonyms
cypC, ybdT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2124 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
229,525  230,778
The protein
Catalyzed reaction/ biological activity
hydroxylation of a long-chain fatty acid (e.g. myristic acid) at the alpha- and beta-positions using hydrogen peroxide as an oxidant PubMed
1,2-saturated fatty acid + H2O2 --> 2-hydroxy fatty acid + H2O (according to UniProt)
2,3-saturated fatty acid + H2O2 --> 3-hydroxy fatty acid + H2O (according to UniProt)
Protein family
cytochrome P450 family (according to UniProt)
Structure
Expression and Regulation
Operons
Genes
Description
(according to DBTBS) null
Regulation
induced by stress (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
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cypC

2024-10-22 12:38:20

ghost

96

ae76bd79407946848abde61a3e08c7ed6beabb6d

345F0917AB91C404C4CF207B6194340F47AB77CA

Biological materials
Mutant
MGNA-B961 (ybdT::erm), available at the NBRP B. subtilis, Japan
BKE02100 (cypC::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCCGCTTACCCTGCCTTC,  downstream forward: _UP4_TAAATTAAAAAGCTCTCTTC
BKK02100 (cypC::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCCGCTTACCCTGCCTTC,  downstream forward: _UP4_TAAATTAAAAAGCTCTCTTC
References
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Page visits: 4425

Time of last update: 2025-01-03 14:50:12

Author of last update: Melvin.boenninger